E588055 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
2.5mg
$ 130.000.0
10mg
$ 480.000.0
25mg
$ 1010.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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E588055

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Product Description

Catalogue NumberE588055
Chemical Name4,5a-Epoxy Eplerenone
Synonyms(4α,5α,7α,11α,17α)-4,5:9,11-Diepoxy-17-hydroxy-3-oxo-γ-lactone-methylester-pregnane-7,21-dicarboxylic Acid
CAS Number209253-73-6
Molecular FormulaC₂₄H₃₀O₇
AppearanceWhite to Off-White Solid
Melting Point>249°C (dec.)
Molecular Weight430.49
Storage-20°C, Hygroscopic
SolubilityChloroform (Slightly, Sonicated), Methanol (Slightly)
Category Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Steroids;
Applications4,5a-Epoxy Eplerenone is an impurity of Eplerenone (E588775), a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
Referencesde Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),