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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 2.5mg | $ 130.00 | 0.0 | |
| 10mg | $ 480.00 | 0.0 | |
| 25mg | $ 1010.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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E588055
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Product Description
| Catalogue Number | E588055 |
| Chemical Name | 4,5a-Epoxy Eplerenone |
| Synonyms | (4α,5α,7α,11α,17α)-4,5:9,11-Diepoxy-17-hydroxy-3-oxo-γ-lactone-methylester-pregnane-7,21-dicarboxylic Acid |
| CAS Number | 209253-73-6 |
| Molecular Formula | C₂₄H₃₀O₇ |
| Appearance | White to Off-White Solid |
| Melting Point | >249°C (dec.) |
| Molecular Weight | 430.49 |
| Storage | -20°C, Hygroscopic |
| Solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
| Category | Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Steroids; |
| Applications | 4,5a-Epoxy Eplerenone is an impurity of Eplerenone (E588775), a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure. |
| References | de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005), |