19-Epi FK-506 Discontinued

Catalogue number: E586520
Chemical name: 19-Epi FK-506 Discontinued
Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19S,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Impurity:
CAS Number: 144490-63-1
Possible CAS #: NA
Molecular form.: C₄₄H₆₉NO₁₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 804.02
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: 19-Epi FK-506 is an impurity in the synthesis of FK-506 [Tacrolimus] (F370000), an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
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