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Pack Size Quantity Price (USD) Sub Total
20mg
$ 120.00 0.0
200mg
$ 960.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Product Description

Catalogue Number: E555800
Chemical Name: ENMD 547
Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine Monohydrobromide;
CAS Number: 644961-61-5
Molecular Formula: C₁₅H₃₀BrN₃O₂
Appearance: N/A
Molecular Weight: 364.32
Category: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
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