D679200 Chemical Structure

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D679200

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Product Description

Catalogue NumberD679200
Chemical NameDroloxifene Citrate
Synonyms3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol 2-Hydroxy-1,2,3-propanetricarboxylate (1:1); (E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol 2-Hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
CAS Number97752-20-0
Alternate CAS #Free Base: 82413-20-5
Molecular FormulaC32H37NO9
AppearanceWhite to Off-White Solid
Melting Point>143°C (dec.)
Molecular Weight579.64
StorageAmber Vial, -20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly)
StabilityLight Sensitive
Category Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsDroloxifene is a non-steroidal anti-oestrogen that is structurally related to Tamoxifen (T006000), a drug used to prevent the occurrence of breast cancer in postmenopausal women. Droloxifene has a very high binding affinity to estrogen receptors and is used, similarly to Tamoxifen, to prevent and treat breast cancer.
ReferencesCoombes, R., et al.: New Engl. J. Med., 350, 1081 (2004); Geisler, J., et al.: J. Ster. Biochem. Mol. Biol., 55, 193 (1995); Hasmann, M., et al.: Cancer Lett., 84, 101 (1994); Powles, T., et al.: Lancet 352, 98 (1998)