Dorsomorphin Dihydrochloride


Catalogue number: D534910
Chemical name: Dorsomorphin Dihydrochloride
Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2)
Impurity:
CAS Number: 1219168-18-9
Alternate CAS #: Free Base: 866405-64-3
Molecular form.: C₂₄H₂₇Cl₂N₅O
Appearance: Yellow Solid
Melting Point: >228°C(dec.)
Mol. Weight: 472.41
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Water (Slightly)
Stability: No Data Available
Category: Aromatics, Protein Kinase Inhibitors and Activators
Boiling Point: No Data Available
Applications: Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
Dangerous Goods Info: NA
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: D534910.pdf
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