D485310 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 135.000.0
25mg
$ 320.000.0
mg50
$ 615.000.0
100mg
$ 975.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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D485310

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Product Description

Catalogue NumberD485310
Chemical Name8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
CAS Number1256584-81-2
Molecular FormulaC28H29N3O3
Molecular Weight455.55
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an intermediate used in the synthesis of Alectinib M4 metabolite (A521150), which is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-​small-​cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK).
ReferencesHeinig, K., et al.: Bioanalysis, 8, 1465-79 (2016); Morcos, P.N., et al.: Xenobiotica, 47, 217-29 (2017);