D479400 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 175.000.0
10mg
$ 330.000.0
25mg
$ 775.000.0
50mg
$ 1505.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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Product Description

Catalogue NumberD479400
Chemical Name42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
Synonyms23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine rapamycin deriv.
CAS Number143030-02-8
Molecular FormulaC57H93NO13Si
AppearanceWhite Solid
Molecular Weight1028.43
Storage-20°C Freezer
SolubilityDichloromethane, Methanol
Category Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin is an intermediate in the synthesis of 8-O-Methyl-rapamycin which is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.