D448620 Chemical Structure

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Product Description

Catalogue NumberD448620
Chemical NameDihydro Bupropion (Threo and Erythro mixture (1:1)) Maleate
Synonyms(αR)-3-Chloro-α-[1-[(1,1-dimethylethyl)amino]ethyl]-benzenemethanol Maleate
Alternate CAS #free base: 292055-72-2 and 153365-82-3
Molecular FormulaC₁₇H₂₄ClNO₅
AppearanceWhite to Off-White Solid
Melting Point>125°C (dec.)
Molecular Weight357.83
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityDMSO, Methanol
Category Research Tools; Chiral Molecules; Ephedrine; Pharmaceutical/API Drug Impurities/Metabolites; Phenethylamines/Amphetamines;
ApplicationsDihydro Bupropion (Threo and Erythro mixture (1:1)) is a metabolite of the drug Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation.
ReferencesSoroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003)