D448593 Chemical Structure

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Product Description

Catalogue NumberD448593
Chemical NameDihydrofluorescein diacetate
Synonyms2-[3,6-Bis(acetyloxy)-9H-xanthen-9-yl]benzoic Acid
CAS Number35340-49-9
Molecular FormulaC24H18O7
Molecular Weight418.4
Category Research Tools; Molecular Biology; Dyes;
ApplicationsDihydrofluorescein diacetate is a chemical used for intracellular staining. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as 2',7'-dichlorodihydrofluorescein and Dihydrorhodamine 123. Dihydrofluorescein diacetate is first hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by hydrogen peroxide.
References1. Hempel, S L., et al., 1999. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free radical biology & medicine. 27(1-2): 146-59. PMID: 10443931