D444105 Chemical Structure

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100mg
$ 150.000.0
250mg
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mg500
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1g
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D444105

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Product Description

Catalogue NumberD444105
Chemical NameDiethyl 2-ethyl-2-(3-methoxybenzyl)malonate
SynonymsEthyl[(3-methoxyphenyl)methyl]-diethyl Ester Propanedioic acid
CAS Number138089-93-7
Molecular FormulaC17H24O5
AppearanceClear oil
Molecular Weight308.37
SolubilityDCM, MeOH, EtOAc
Category Building Blocks; Miscellaneous;
ApplicationsDiethyl 2-ethyl-2-(3-methoxybenzyl)malonate is an intermediate in the synthesis of cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (D445070), a fluorescent and selective ligand that can be used to investigate the interactions between ligand and receptor of estrogen receptors (ERs) (1,2,3). cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is an ERα agonist and an ERβ antagonist.
ReferencesSumbayev, V. V., et al.: Mol Cell Endocrinol 287, 30 (2008), Dobrydneva, Y., et al.: J. Cardiovasc. Pharmacol., 40, 399 (2002), Rosado, J., et al.: Biochem. J., 350, 631 (2000).