D299050 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 110.000.0
50mg
$ 150.000.0
250mg
$ 450.000.0
Exact Weight Packaging
$ 95.000.0
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  • Ships On : 12/23/2021
D299050

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Product Description

Catalogue NumberD299050
Chemical NameDexrazoxane
Synonyms4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione; (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione; (+)-4,4'-Propylenedi-2,6-piperazinedione; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; ADR 529; ICRF 187; NSC 169780; Savene; Totect; Zinecard
CAS Number24584-09-6
Molecular FormulaC₁₁H₁₆N₄O₄
AppearanceWhite to Pale Yellow solid
Melting Point>186°C (dec.)
Molecular Weight268.27
StorageRefrigerator
SolubilityDMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsDexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
ReferencesWalker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)