N-[[P(S),2’R]-2’-deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-P-phenyl-5’-uridylyl]-L-alanine 1-Methylethyl Ester

Catalogue number: D233030
Chemical name: N-[[P(S),2’R]-2’-deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-P-phenyl-5’-uridylyl]-L-alanine 1-Methylethyl Ester
CAS Number: 1256490-54-6
Possible CAS #: NA
Molecular form.: C₂₈H₄₃FN₃O₉PSi
Appearance: White Solid
Melting Point: No Data Available
Mol. Weight: 643.71
Storage: No Data Available
Solubility: Chloroform, Dichloromethane, Methanol
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N-[[P(S),2’R]-2’-deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-P-phenyl-5’-uridylyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Dangerous Goods Info: NA
Peer Review Product Citations:
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  Pack size Price(USD)
2.5mg $150.00
10mg $450.00
  Pack size Price(USD)
5mg $250.00
25mg $1050.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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