(2’R)-2’-Deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine


Catalogue Number: D233025
Chemical Name: (2’R)-2’-Deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine
CAS Number: 1244762-86-4
Molecular Formula: C₁₆H₂₇FN₂O₅Si
Appearance: White Solid
Melting Point: 230-232°C
Molecular Weight: 374.48
Storage: -20°C Freezer
Solubility: DMSO (Slightly), Methanol (Slightly)
Applications: (2’R)-2’-Deoxy-3’-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
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All Products are stable to be shipped at room temperature, unless otherwise specified.
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