Catalogue Number: D233020
Chemical Name: (2’R)-2’-Deoxy-3’,5’-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine
CAS Number: 1393526-40-3
Molecular Formula: C₂₂H₄₁FN₂O₅Si₂
Appearance: Pale Yellow Oil
Molecular Weight: 488.74
Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Applications: (2’R)-2’-Deoxy-3’,5’-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
10mg $170.00
50mg $575.00
  Pack size Price(USD)
25mg $300.00
100mg $1035.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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