D231405 Chemical Structure

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D231405

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Product Description

Catalogue NumberD231405
Chemical Name4-Demethoxy-4-hydroxy Apixaban
Synonyms4,5,6,7-Tetrahydro-1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number503612-76-8
Molecular FormulaC24H23N5O4
AppearanceWhite to Pale Beige Solid
Melting Point>250°C (dec.)
Molecular Weight445.47
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityDMSO (Slightly), Methanol (Slightly, Heated)
StabilityHygroscopic
Category Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications4-Demethoxy-4-hydroxy Apixaban is a metabolite of Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa.
ReferencesLuettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);