4-Defluoro-4-(p-fluorophenyl)aprepitant


Catalogue number: D228720
Chemical name: 4-Defluoro-4-(p-fluorophenyl)aprepitant
Synonyms: 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4’-fluoro-[1,1’-biphenyl]-4-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
Impurity:
CAS Number: NA
Alternate CAS #: NA
Molecular form.: C₂₉H₂₅F₇N₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 610.52
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Chiral Reagents, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: 4-Defluoro-4-(p-fluorophenyl)aprepitant is an impurity of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
Dangerous Goods Info: NA
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
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