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5mg
$ 150.00 0.0
50mg
$ 1200.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
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Product Description

Catalogue Number: D228720
Chemical Name: 4-Defluoro-4-(p-fluorophenyl)aprepitant
Synonyms: 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
Molecular Formula: C₂₉H₂₅F₇N₄O₃
Molecular Weight: 610.52
Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: 4-Defluoro-4-(p-fluorophenyl)aprepitant is an impurity of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
References
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