Defluoro Dolutegravir


Catalogue Number: D228715
Chemical Name: Defluoro Dolutegravir
Synonyms: (4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;
CAS Number: 1863916-88-4
Molecular Formula: C₂₀H₂₀FN₃O₅
Appearance: Off-White Solid
Melting Point: >166°C (dec.)
Molecular Weight: 401.39
Storage: -20°C Freezer
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Applications: Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
0.5mg $150.00
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5mg $1275.00
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  Pack size Price(USD)
2.5mg $695.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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