D205065 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 200.000.0
10mg
$ 375.000.0
25mg
$ 915.000.0
50mg
$ 1585.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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D205065

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Product Description

Catalogue NumberD205065
Chemical NameDocetaxel 2'-tert-Butyldimethylsilyl 7,10-Tris(triethylsilyl) Ether
Synonyms(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4,6-bis[(triethylsilyl)oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-benzenepropanoic Acid Ester;
CAS Number195141-96-9
Molecular FormulaC₆₁H₉₅NO₁₄Si₃
AppearanceWhite Solid
Molecular Weight1150.66
StorageRefrigerator, under inert atmosphere
SolubilityChloroform; Methanol;
Category Building Blocks; Standards; Chiral Molecules; Miscellaneous; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsDocetaxel 2'-tert-Butyldimethylsilyl 7,10-Tris(triethylsilyl) Ether is an intermediate used in the synthesis of 2-Debenzoyl-2-pentenoyldocetaxel (D205050), which is a related compound of Docetaxel (D494420), a chemotherapy drug that exhibits anti-mitotic properties and used for treating various metastatic cancers.
ReferencesYokoyama, G., et al.: Int J Clin Oncol 10, 139 (2005); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)