D121020 Chemical Structure

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0.5mg
$ 130.000.0
1mg
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2.5mg
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5mg
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$ 95.000.0
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D121020

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Product Description

Catalogue NumberD121020
Chemical NameDes-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27
Synonyms2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-3-hydroxy-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide
Molecular FormulaC₄₅H₅₀ClN₇O₈S
Molecular Weight884.45
Category Building Blocks; Miscellaneous;
ApplicationsDes-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27 is an intermediate in the synthesis of Venetoclax-M27 (V121010), a derivative of Venetoclax (ABT 199), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
ReferencesDavids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A., et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);