Have a question about this product Click here.
All Products are stable to be shipped at room temperature, unless otherwise specified.
|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||
||$ 75.00 / Vial||0.0|
Product successfully added to cart.
Request another packsize ? Click here.
Inventory Status : Currently Back Ordered - Please Request Lead Time
Bulk Order Request for W950000
|Chemical Name:||WYE 354|
|Synonyms:||4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester; WYE-354;|
|Category:||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications:||A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.|
Customers Also Viewed
Keywords: Buy 1062169-56-5 | Purchase 1062169-56-5 | Order 1062169-56-5 | 1062169-56-5 supplier | 1062169-56-5 manufacturer | 1062169-56-5 distributor | 1062169-56-5 cost