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$ 275.000.0
$ 2200.000.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
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Product Description

Catalogue Number:T006002
Chemical Name:Tamoxifen-13C6
Synonyms:(Z)-2-[4-[1-(phenyl-13C6)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine; ICI 47699-13C6; Mammaton-13C6; Novaldex-13C6; Tamoxifen-13C6; Z-Tamoxifen-13C6; trans-Tamoxifen-13C6;
CAS Number:1346606-38-9
Alternate CAS #:unlabelled: 10540-29-1
Molecular Formula:C₂₀¹³C₆H₂₉NO
Appearance:Off-White Solid
Melting Point:94 - 99°C
Molecular Weight:377.47
Storage:Amber Vial, -20°C Freezer
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category: Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.