Catalogue Number: S684700
Chemical Name: Stauprimide
Synonyms: N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; N-Benzoyl-7-oxostaurosporine;
CAS Number: 154589-96-5
Molecular Formula: C₃₅H₂₈N₄O₅
Molecular Weight: 584.62
Solubility: DMSO (20mg/mL); only slightly soluble in EtOH
Category: Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: Stauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased definitive endodermal markers but not markers for visceral/parietal endoderm or mesoderm. Stauprimide-differentiated cells could be further differentiated into hepatocytes. Stauprimide treatment during differentiation decreased the concentration of Activin A required for definitive endoderm formation, and it eliminated the need for serum. The mechanism

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