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10mg
$ 110.00 0.0
100mg
$ 880.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
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Product Description

Catalogue Number: S199900
Chemical Name: SC-514
Synonyms: 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; 4-Amino-[2,3'-bithiophene]-5-carboxamide;
CAS Number: 354812-17-2
Molecular Formula: C₉H₈N₂OS₂
Appearance: Yellow Solid
Melting Point: 209-211°C
Molecular Weight: 224.3
Solubility: DMSO
Category: Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications: A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
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