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Pack Size Quantity Price (USD) Sub Total
500µg
$ 80.00 0.0
1mg
$ 125.00 0.0
2mg
$ 225.00 0.0
5mg
$ 375.00 0.0
10mg
$ 725.00 0.0
25mg
$ 1800.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : Pending QC

Ships On: 11/11/2019

Bulk Order Request for R425060

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Product Description

Catalogue Number: R425060
Chemical Name: Romidepsin
Synonyms: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide; [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone Cyclic (12)-Disulfide; Antibiotic FR 901228; Chromadax; FK 228; FR 901228; NSC 630176;
CAS Number: 128517-07-7
Molecular Formula: C₂₄H₃₆N₄O₆S₂
Appearance: White to Off-White Solid
Melting Point: 219-224°C
Molecular Weight: 540.7
Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Category: Standards; Enzyme Activators and Inhibitors; Others; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications: Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
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