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Pack Size Quantity Price (USD) Sub Total
5mg
$ 85.00 0.0
10mg
$ 150.00 0.0
25mg
$ 320.00 0.0
50mg
$ 545.00 0.0
100mg
$ 995.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : Pending QC

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Product Description

Catalogue Number: P294400
Chemical Name: PHA-543613 Dihydrochloride
Synonyms: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride; PHA 543613E;
CAS Number: 478148-58-2
Alternate CAS #: free base: 478149-53-0
Molecular Formula: C₁₅H₁₉Cl₂N₃O₂
Appearance: Tan Solid
Melting Point: >300˚C
Molecular Weight: 344.24
Storage: Refrigerator
Solubility: DMSO, Methanol
Category: Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
References
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