All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack Size Quantity Price (USD) Sub Total
5mg
$ 55.00 0.0
10 mg
$ 70.00 0.0
25 mg
$ 85.00 0.0
50 mg
$ 160.00 0.0
100 mg
$ 305.00 0.0
250 mg
$ 675.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : Pending QC

Bulk Order Request for P132000

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Product Description

Catalogue Number: P132000
Chemical Name: PAC-1
Synonyms: 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl] methylene]hydrazide; Procaspase Activating Compound 1
CAS Number: 315183-21-2
Molecular Formula: C₂₃H₂₈N₄O₂
Molecular Weight: 392.49
Category: Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
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