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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||
||$ 75.00 / Vial||0.0|
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Inventory Status : Pending QC
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|Synonyms:||4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide; Procaspase Activating Compound 1|
|Category:||Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications:||PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.|
|Dangerous Goods Info:||Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package|