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Product Description

Catalogue Number: K450000
Chemical Name: Kifunensine
Synonyms: [5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine; FR 900494
CAS Number: 109944-15-2
Molecular Formula: C₈H₁₂N₂O₆
Appearance: White to Off-White Solid
Melting Point: >208°C (dec.)
Molecular Weight: 232.19
Storage: -20°C Freezer
Solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Very Slightly, Heated)
Stability: Desiccate and Store at -20°C
Category: Standards; Enzyme Activators and Inhibitors; Glycosidase Inhibitors;
Applications: Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis. When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin. Ph
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