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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||
||$ 75.00 / Vial||0.0|
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|Synonyms:||[5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine; FR 900494|
|Appearance:||White to Off-White Solid|
|Melting Point:||>208°C (dec.)|
|Solubility:||DMSO (Slightly, Heated), Methanol (Slightly), Water (Very Slightly, Heated)|
|Stability:||Desiccate and Store at -20Â°C|
|Category:||Standards; Enzyme Activators and Inhibitors; Glycosidase Inhibitors;|
|Applications:||Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph|
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