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10mg
$ 155.00 0.0
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Product Description

Catalogue Number: I163900
Chemical Name: iCRT-14
Synonyms: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14;
CAS Number: 677331-12-3
Molecular Formula: C₂₁H₁₇N₃O₂S
Appearance: Light Yellow Solid
Melting Point: 183-186°C
Molecular Weight: 375.44
Storage: -20°C Freezer
Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
Category: Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
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