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Product Description

Catalogue Number: H926307
Chemical Name: Hydroxy Cyclophosphamide Semicarbazone-d4 (>80%)
Synonyms: N,N-bis(2-chloroethyl)phosphorodiamidic Acid 3-[2-(Aminocarbonyl)hydrazinylidene]propyl Ester-d4; NSC 319519-d4; Aldophosphamide Semicarbazone-d4
Alternate CAS #: Unlabelled: 53948-46-2
Molecular Formula: C₈H₁₄D₄Cl₂N₅O₃P
Appearance: Off-White to Pale Yellow Solid
Melting Point: 102-104°C
Molecular Weight: 338.16
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: Hygroscopic
Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Isotope labelled Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This compound is suitable for aldehyde dehydrogenase (ALDH) related research.