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Product Description

Catalogue Number: H926305
Chemical Name: Hydroxy Cyclophosphamide Semicarbazone (80%)
Synonyms: N,N-bis(2-chloroethyl)phosphorodiamidic Acid 3-[2-(Aminocarbonyl)hydrazinylidene]propyl Ester; NSC 319519; Aldophosphamide Semicarbazone;
CAS Number: 53948-46-2
Molecular Formula: C₈H₁₈Cl₂N₅O₃P
Appearance: Colourless to Pale Yellow Oil to Low-Melting Solid
Molecular Weight: 334.14
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly)
Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
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