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$ 1055.00 0.0
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Product Description

Catalogue Number: G797415
Chemical Name: GSK 5072 Dihydrochloride
Synonyms: 5-(((4-Chlorobenzyl)(pyridin-3-ylmethyl)amino)methyl)thiophene-2-carbonitrile Dihydrochloride; 5-[[[(4-Chlorophenyl)methyl](3-pyridinylmethyl)amino]methyl]-2-thiophenecarbonitrile Dihydrochloride;
Alternate CAS #: Free Base: 1438071-23-8
Molecular Formula: C₁₉H₁₆ClN₃S • 2(HCl)
Appearance: Off-White to Pale Yellow Solid
Melting Point: >137ºC (dec.)
Molecular Weight: 353.8723646
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
Category: Research Tools; Molecular Biology;
Applications: GSK 5072 Dihydrochloride is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.