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Product Description

Catalogue Number: G797405
Chemical Name: GSK 2945 Hydrochloride
Synonyms: N-(4-Chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine Hydrochloride; N-[(4-Chloro-2-methylphenyl)methyl]-N-[(4-chlorophenyl)methyl]-5-nitro-2-thiophenemethanamine Hydrochloride
Alternate CAS #: Free Base: 1438071-12-5
Molecular Formula: C₂₀H₁₈Cl₂N₂O₂S .HCl
Appearance: Off-White to Light Beige Solid
Melting Point: >79ºC (dec.)
Molecular Weight: 421.343646
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
Category: Research Tools; Molecular Biology;
Applications: GSK 2945 Hydrochloride, is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.