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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||
||$ 75.00 / Vial||0.0|
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|Chemical Name:||Fingolimod Hydrochloride|
|Synonyms:||2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride;|
|Alternate CAS #:||Free Base: 162359-55-9|
|Appearance:||White to Off-White Solid|
|Melting Point:||>106°C (dec.)|
|Solubility:||DMSO (Slightly), Methanol (Slightly), Water (Slightly)|
|Category:||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications:||Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).|