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Product Description

Catalogue Number: E555802
Chemical Name: ENMD 547-d8
Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine-d8 Monohydrobromide;
CAS Number: 1795025-33-0
Alternate CAS #: unlabelled: 644961-61-5
Molecular Formula: C₁₅H₂₂D₈BrN₃O₂
Appearance: N/A
Molecular Weight: 372.37
Category: Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: ENMD 547-d8 is deuterium labeled ENMD 547, a selective PAR-2 antagonist (1, 2). Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.