All Products are stable to be shipped at room temperature, unless otherwise specified.
|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 75.00 / Vial||0.0|
Product successfully added to cart.
Request another packsize ? Click here.
Inventory Status : Currently Back Ordered - Please Request Lead Time
Bulk Order Request for E555800
|Chemical Name:||ENMD 547|
|Synonyms:||6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine Monohydrobromide;|
|Category:||Standards; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications:||A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.|