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Product Description

Catalogue Number: D428050
Chemical Name: Di-(tert-Butyl-dimethylsilyl) Curcumin
Synonyms: (1E,4Z,6E)-1,7-Bis[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1,4,6-heptatrien-3-one
CAS Number: 1134639-23-8
Molecular Formula: C₃₃H₄₈O₆Si₂
Appearance: Yellow Solid
Melting Point: 138-140ºC
Molecular Weight: 596.9
Storage: Refrigerator
Solubility: Chloroform (Slightly), Methanol (Slightly)
Category: Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
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