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Pack Size Quantity Price (USD) Sub Total
10mg
$ 95.00 0.0
50mg
$ 225.00 0.0
250mg
$ 350.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Product Description

Catalogue Number: C051500
Chemical Name: Cabozantinib L-Malate Salt
Synonyms: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; XL 184;
CAS Number: 1140909-48-3
Alternate CAS #: 849217-68-1-free base
Molecular Formula: C₃₂H₃₀FN₃O₁₀
Appearance: White to Off-White Solid
Melting Point: 166-169°C
Molecular Weight: 635.59
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Category: Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
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