A 77-1726

Catalogue Number: A771726
Chemical Name: A 77-1726
Synonyms: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide; Leflunomide EP Impurity B; Aubagio; A1726; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix; HMR 1726; SU 20
Impurity: Leflunomide EP Impurity B
CAS Number: 163451-81-8
Alternate CAS #: 108605-62-5 (Unspecified Stereochemistry)p
Molecular Formula: C₁₂H₉F₃N₂O₂
Appearance: White Solid
Melting Point: 229-232°C
Molecular Weight: 270.21
Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility: DMSO, Methanol (Sparingly)
Category: Metabolites & Impurities, Tyrosine Kinase Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).

All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: A771726.pdf
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500mg $185.00
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10mg $90.00
50mg $150.00
1g $245.00

Exact Weight Packaging ($75(USD) / Vial)
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