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Pack Size Quantity Price (USD) Sub Total
1mg
$ 250.00 0.0
10mg
$ 2000.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
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Product Description

Catalogue Number: A105037
Chemical Name: Abacavir-d4 5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Synonyms: N6-Cyclopropyl-d4-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir-d4 Related Compound D; Abacavir Stable Isotope
Alternate CAS #: Unlabelled: 1443421-69-9
Molecular Formula: C₁₈H₁₇D₄ClN₁₀O
Molecular Weight: 432.9
Category: Building Blocks; Isotopic Labeled Analogues;
Applications: Abacavir-d4 5’-4-Chloro-6-methylpyrimidine-2,5-diamine is deuterium labeled Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (A105035), a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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