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Pack Size Quantity Price (USD) Sub Total
1mg
$ 140.00 0.0
10mg
$ 1120.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : Pending QC

Bulk Order Request for A105030

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Product Description

Catalogue Number: A105030
Chemical Name: Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester
Molecular Formula: C₃₃H₄₆N₆O₁₀
Appearance: Off-White Solid
Molecular Weight: 686.75
Solubility: Chloroform, Dichloromethane, DMSO, Methanol
Category: Amines, Aromatics, Glucuronides, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References
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