ent-Abacavir


Catalogue number: A105015
Chemical name: ent-Abacavir
Synonyms: (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A; Abacavir Impurities; Ent-Abacavir
Impurity: Abacavir EP Impurity A
CAS Number: 136470-79-6
Alternate CAS #: NA
Molecular form.: C₁₄H₁₈N₆O
Appearance: Off-White to Pale Yellow Solid
Melting Point: >77°C (dec.)
Mol. Weight: 286.33
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Anti-virals, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:


All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
1mg $95.00
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25mg $1400.00
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  Pack size Price(USD)
2.5mg $175.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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