trans-Abacavir-d4 Hydrochloride


Catalogue Number: A104997
Chemical Name: trans-Abacavir-d4 Hydrochloride
Synonyms: (1R,4R)-rel-4-[2-Amino-6-[cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; Abacavir Stable Isotope
CAS Number: 1346605-40-0
Alternate CAS #: 267668-71-3-unlabelled
Molecular Formula: C₁₄H₁₅D₄ClN₆O
Molecular Weight: 326.82
Category: Inhibitors, Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: trans-Abacavir-d4 Hydrochloride is deuterium labeled trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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All Products are stable to be shipped at room temperature, unless otherwise specified.
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