trans-Abacavir Dihydrochloride


Catalogue Number: A104995
Chemical Name: trans-Abacavir Dihydrochloride
Synonyms: (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride;
Alternate CAS #: (HCl 1:1): 267668-71-3; 783292-37-5-free base
Molecular Formula: C₁₄H₂₀Cl₂N₆O
Appearance: Pale Yellow to Pale Orange Solid
Melting Point: >144°C (dec.)
Molecular Weight: 359.25
Storage: Refrigerator
Solubility: DMSO, Water (Slightly)
Category: Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Applications: trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References:


All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: A104995.pdf
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  Pack size Price(USD)
1mg $150.00
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25mg $975.00
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100mg $2325.00
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  Pack size Price(USD)
10mg $775.00
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50mg $1525.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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