Abacavir 5’-β-D-Glucuronide Sodium Salt


Catalogue number: A104985
Chemical name: Abacavir 5’-β-D-Glucuronide Sodium Salt
Synonyms: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
Impurity:
CAS Number: NA
Alternate CAS #: 384329-76-4 free acid
Molecular form.: C₂₀H₂₅N₆NaO₇
Appearance: Pale Beige Solid
Melting Point: >206°C (dec.)
Mol. Weight: 484.44
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Methanol (Slightly), Water (Slightly)
Stability: Hygroscopic
Category: No Data Available
Boiling Point: No Data Available
Applications: Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:


All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
1mg $175.00
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5mg $615.00
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  Pack size Price(USD)
2mg $325.00
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10mg $1195.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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