TRC | Details of CAS = 1166227-08-2, ChemicalName = A66, synonym = (2S)-N1-[2-(1,1-Dimethylethyl)-4’-methyl[4,5’-bithiazol]-2’-yl]-1,2-pyrrolidinedicarboxamide; (2S)-1-N-[5-(2-tert-Butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide, MolFormula = C₁₇H₂₃N₅O₂S₂

Catalogue Number:	A101100
Chemical Name:	A66
Synonyms:	(2S)-N1-[2-(1,1-Dimethylethyl)-4’-methyl[4,5’-bithiazol]-2’-yl]-1,2-pyrrolidinedicarboxamide; (2S)-1-N-[5-(2-tert-Butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
CAS Number:	1166227-08-2
Molecular Formula:	C₁₇H₂₃N₅O₂S₂
Molecular Weight:	393.53
Category:	Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Applications:	A66 is a potent and specific p110α inhibitor. Inhibition of p110α can block phosphoinositide 3-kinase (PI3K) signalling and tumor growth in certain cell types.
References:	Jamieson, S., et al.: Biochem. J., 438, 53 (2011); Wang, X., et al.: Acta Pharmacol. Sin., 34, 1201 (2013); Smith, G.C., et al.: FEBS J., 280, 5337 (2013)

	All Products are stable to be shipped at room temperature, unless otherwise specified.





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