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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 75.00 / Vial||0.0|
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|Chemical Name:||A-1155463 Hydrochloride|
|Synonyms:||2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride;|
|Alternate CAS #:||Free Base: 1235034-55-5|
|Melting Point:||>140°C (dec.)|
|Storage:||-20°C Freezer, Under inert atmosphere|
|Solubility:||Chloroform (Slightly, Heated), DMSO (Slightly)|
|Category:||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications:||A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killi|
|Dangerous Goods Info:||Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package|