C989195 Chemical Structure

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C989195

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Product Description

Catalogue NumberC989195
Chemical Name((4S)-4-Cyclohexyl-1-[(R)-[(S)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl-D-proline Propionate (Ester) Hemibarium Salt Sesquihydrate)
SynonymsUSP Fosinopril Related Compound B; (D-Proline) Fosinopril Hemibarium Salt Sesquihydrate;
Alternate CAS #Fosinopril: 98048-97-6
Molecular FormulaC₃₀H₄₆NO₇P • 0.5Ba • 1.5H ₂O
Molecular Weight658.34
Category Building Blocks;
Applications((4S)-4-Cyclohexyl-1-[(R)-[(S)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl-D-proline Propionate (ester) Hemibarium Salt Sesquihydrate) is an impurity in the synthesis of Fosinopril (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
ReferencesSinghvi, S.M., et al.: Br. J. Clin. Pharmacol., 25, 9 (1988), Sullivan, P.A., et al.: Am. J. Hypertension, 1, 280S (1988),