C694995 Chemical Structure

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C694995

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Product Description

Catalogue NumberC694995
Chemical Name(-)-Corey Lactone Diol
Synonyms(3aR,4S,5R,6aS)Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; [3aR-(3aα,4α,5β,6aα)]Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one;
CAS Number32233-40-2
Molecular FormulaC₈H₁₂O₄
AppearanceLight Beige to Beige Solid
Melting Point118-120°C
Molecular Weight172.18
Storage-20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly)
Category Building Blocks; Chiral Molecules;
Applications(-)-Corey Lactone Diol is an intermediate of Iloprost (I267300) and shows inhibitory activity towards β-lactamase. Iloprost (I267300) is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia.
ReferencesGal, Z. et al.: J. Chemother., 12, 274 (2000); Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008);