C562500 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
50µg
$ 60.000.0
100µg
$ 105.000.0
500µg
$ 430.000.0
1mg
$ 760.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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C562500

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Product Description

Catalogue NumberC562500
Chemical NameClasto-lactacystin (Omuralide)
Synonyms(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Clasto-lactacystin β-Lactone; Omuralide
CAS Number154226-60-5
Molecular FormulaC₁₀H₁₅NO₄
AppearanceWhite Solid
Melting Point186-187°C
Molecular Weight213.23
Storage-20°C Freezer
SolubilityDMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
Category Standards; Enzyme Activators and Inhibitors;
ApplicationsA cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
ReferencesCraiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)