C379830 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 150.000.0
50mg
$ 935.000.0
200mg
$ 2380.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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  • Ships On : 12/23/2021
C379830

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Product Description

Catalogue NumberC379830
Chemical Name(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Synonyms(2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide; Avagacestat; BMS 708163; BMS 708163-01;
CAS Number1146699-66-2
Molecular FormulaC₂₀H₁₇ClF₄N₄O₄S
AppearanceWhite Solid
Melting Point157-160°C
Molecular Weight520.88
StorageRefrigerator
SolubilityChloroform (Slightly), Methanol (Slightly)
Category Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAvagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.
ReferencesHarris, PJ. et al.: Expert. Opin. Ther. Tar., 16, 131 (2012); Gilman, K.W. et al.: ACS Med. Chem. Lett., 1, 120 (2010);